Videos

Watch our live demo from the CSD Launch on February 15, 2022.


Watch a CSD tutorial on how to enhance your Abstract Search. October 17, 2022. 


Webinars


Illuminate the Science - Webinar 1: In honor of men's health month, we focused on using the database to gain insights on the research on EPA and DHA supplementation and cardiovascular disease and other conditions in men. 

  • Passcode: q+9a28bx
  • June 23, 2022.  


 

Illuminate the Science Webinar 2: This webinar focused on cognitive health and brain health, spelling out the different dimensions, challenges and opportunities related to the topic and their relationships to omega-3s. There are many cognitive tests used to measure outcomes in omega-3 studies and this creates challenges in streamling intake recommendations for brain health. 

  • Passcode: SLS%Jr69
  • December 7, 2022.  



Illuminate the Science Webinar 3: This webinar focused on the link between EPA and DHA omega-3s and inflammation, describing what inflammation is and how it can be explained to the consumers. The biology of the inflammatory response related to EPA and DHA omega-3s is explained with a brief discussion of various eicosanoids and metabolites. The Clinical Study Database is showcased to describe how to search for inflammation as an outcome of an interventional study. 

  • Passcode: e7fr@ArX
  • July 27, 2023.


Illuminate the Science Webinar 4: This webinar starts by explaining immune health and immunity. The role of EPA and DHA omega-3 and immune health are explained, and various mechanisms are outlined to explain their possible effect on overall immune health. The Clinical Study Database is showcased to explain how a search for immune health outcomes could be conducted. Details from some selected studies are highlighted. 

  • Passcode: DP5h!v25
  • December 12, 2023. 


Publications

Arteriosclerosis Report 

  • This report shows the strength of the evidence on arteriosclerosis and EPA+DHA omega-3s through the evaluation of interventional studies, also providing a use case for GOED's unique Clinical Study Database (CSD).
  • This report covers research specific to EPA+DHA across 90% of all abstracts published to date and across interventional studies published to the end of 2019. This report was published in September 2022.
  • GOED members can access this report by signing into their GOED member accounts and searching for "Scientific Reports". Non-GOED members can contact csd@goedomega3.com for more information.


Other Reports

Did you know we also have two reports on skin health? We have one report on Psoriasis and one report on Dermatitis published in 2022. We also have a scoping review on brain health published in 2023, and a *new" report on the evidence on exercise and exercise outcomes through the evaluation of interventional studies published in 2023. 

Psoriasis Report

Dermatitis Report 

Brain Health Review 

Exercise Outcomes Review and Report 

Email csd@goedomega3.com for more information. 

Methods Behind the GOED Clinical Study Database

We published a paper in August 2022 describing the methods behind the development of the GOED Clinical Study Database. "Development of a novel database to review and assess the clinical effects of EPA and DHA omega-3 fatty acids." Aldo A Bernasconi, Allison M Wilkin, Kaitlin Roke, Adam Ismail. Prostaglandins, Leukotrienes and Essential Fatty Acids. Volume 183, 102458, ISSN 0952-3278. 2022."


Abstract: Due to their multiple mechanisms of biological action, eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) have been the focus of ongoing active research for decades. In spite of the resulting body of knowledge, there remain significant gaps in our understanding of EPA/DHA health effects. Further, the volume of existing research makes it challenging to conduct systematic investigations to identify or resolve those gaps. The purpose of this article is to introduce the GOED Clinical Study Database (CSD), a comprehensive, manually-curated relational database that catalogs this research.


Review using the GOED Clinical Study Database

We published a paper in January 2023 describing the complexity of the science surrounding cognitive health. "New perspectives on randomized controlled trails with omega-3 fatty acid supplements and cognition: A scoping review" B. Andriambelo, M. Stiffel, K. Roke, M. Plourde. Ageing Research Reviews. Volume 85, 101835, ISSN 1568-1637. 2023."


Abstract: Long chain polyunsaturated omega-3 fatty acids (n-3 FA), such as eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), are known to be important components in a healthy diet and contribute to healthy functioning of the heart and the brain, among other organs. Although there are epidemiological studies on the strong relationship between fish or n-3 FA consumption and lower risk of cognitive decline, results from randomized controlled trials (RCTs) are less consistent. Here, we performed a scoping review on RCTs with n-3 FA supplementation where cognition was evaluated. Seventy-eight RCTs published before April 2022 were included in this review. Among these RCTs, 43.6% reported a positive cognitive outcome after the consumption of n-3 FA compared to the placebo. However, there was a large diversity of populations studied (age ranges and health status), wide range of doses of EPA + DHA supplemented (79 mg/day – 5200 mg/day) and a multitude of tests evaluating cognition, mainly diagnostic tests, that were used to assess cognitive scores and overall cognitive status. RCTs were thereafter categorized into non-cognitively impaired middle-aged adults (n = 24), non-cognitively impaired older adults (n = 24), adults with subjective memory complaints (n = 14), adults with mild cognitive impairments (MCI, n = 9) and people with diagnosed dementia or other cognitive changes (n = 7). Among these categories, 66.7% of RCTs conducted with MCI adults reported a positive cognitive outcome when supplemented with n-3 FA vs. the placebo. Therefore, this scoping review provides rationale and questions to a) strengthen the design of future RCTs with n-3 FA for cognitive outcomes, and b) generate more informative data to support clinicians in their practice in assessing cognition before and after a nutritional intervention.

Use Cases: 

Our database is still new and we are working hard to gather information from our subscribers on how and why they are using this tool. 

If you are interested in doing a project with us, please contact our Director of Scientific Communication and Outreach csd@goedomega3.com.


Case Study 1: Using the GOED Clinical Study Database (CSD) to Support the Preparation of a Health Claim Petition. November 7, 2022.

In 2014, GOED commissioned a meta-analysis reviewing the evidence for intake of EPA and DHA omega-3s on blood pressure in randomized controlled trials (RCTs). The results of this publication formed the basis for the US Food and Drug Administration’s (FDA) 2019 ruling allowing a qualified health claim that consuming EPA and DHA intake may reduce the risk of hypertension and coronary heart disease. As part of this project, an extensive review of the literature was undertaken. Since this was before the existence of the CSD, we thought it would be interesting to show how the CSD could have been used to compile the research for the project. Click here or the image below to view our video on the topic.

As a reminder, this study showed that EPA and DHA omega-3s are as effective, if not more effective, in lowering blood pressure as some commonly recommended lifestyle changes.




Case Study 2: Using the GOED Clinical Study Database (CSD) for a systematic review or meta-analysis.

One of the most important benefits of using the CSD is how it can help to save people time. The database research team reviews all abstracts that appeared to be about EPA and DHA, and only keeps those in the database that were relevant. This is a hugely time consuming process that the research groups would undertake. What used to take months now takes minutes. A typical systematic review and meta-analysis project may take anywhere from several months to a year to complete depending on how many people were working on the project. The CSD uses PubMed as its background database. So if a research group wants to use the CSD, they may also choose to cross-reference with an additional academic database. Click here or the image below to watch our video on this topic.


Testimonials

We are working to gather information from our subscribers on their experiences using this tool. Thank you to those who have contributed so far. 

Yunpeng Ding Director R&D, Human Nutrition, Aker Biomarine AS
“Our science team has been using the GOED Clinical Study Database since its initial launch in 2021. The tools and functionalities that the database provide are very easy to learn and use. The delivered results meet our expectations and can often guide us in our daily work. In addition, the staff is keen to feedbacks and works hard to improve functionalities and user experience. I think this is a great scientific database for the industry!” July 2022.
Yunpeng Ding
Director R&D, Human Nutrition, Aker Biomarine AS
Theresa Jahn Senior Innovation Manager, Nature's Way Canada
"The GOED Clinical Study Database has been an excellent resource to assist in navigating the literature on omega-3 fatty acids. The easy to navigate dashboard and the filters have saved us a tremendous amount of time." August 2022.
Theresa Jahn
Senior Innovation Manager, Nature's Way Canada
Barbara Davis Nutrition and Regulatory Affairs, Nuseed Nutritional
“We are using the GOED clinical study database for efficiently finding answers to our omega-3 science questions. It is an excellent go-to resource that facilitates locating data efficiently. I especially appreciate how comprehensive the database is and its ease of use.” December 2022
Barbara Davis
Nutrition and Regulatory Affairs, Nuseed Nutritional
Jolie Root Senior Nutritionist and Educator, Carlson Laboratories
"One of the most exciting things about Omega-3 research is the sheer volume of the published studies. Staying informed, given the rapid expansion of this volume of evidence, has always been a challenge. Until now! GOED's Clinical Studies Database is a phenomenal tool for me and my whole team. The database is now the first place we look. Thank you GOED for making my job easier!" March 2023
Jolie Root
Senior Nutritionist and Educator, Carlson Laboratories
Adin Smith Nutrition Research Scientist, Nordic Naturals
"Having access to the Clinical Studies Database is essential for all companies providing omega-3 products. You'll have contact with a network of GOED experts to address all your database-related questions. This team can also handle your clinical and regulatory inquiries that inevitably arise when using the database for product substantiation." September 2023
Adin Smith
Nutrition Research Scientist, Nordic Naturals
Derek Tobin Business Development and Clinical Science Manager, Epax Norway AS
"Keeping an overview of all the publications in omega-3 research is difficult and I often get questions regarding efficacy of omega-3s in all sorts of conditions. My first choice is to screen the GOED clinical database. I know this will give me dedicated results for omega-3s so I save time sorting through non-related articles, and it sorts publications usefully into intervention trials or meta-analyses etc. In addition I can get a quick overview of whether studies were successful. The GOED CSD is a powerful tool together with Pubmed or other search engines and I would recommend its use as a good source of published data in omega-3s." October 2023
Derek Tobin
Business Development and Clinical Science Manager, Epax Norway AS

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